“Irritable bowel syndrome (IBS) is a group of symptoms that occur together, including repeated pain in your abdomen and changes in your bowel movements, which may be diarrhea, constipation, or both. With IBS, you have these symptoms without any visible signs of damage or disease in your digestive tract. IBS is a functional gastrointestinal (GI) disorder.”
NIH National Institute of Diabetes and Digestive and Kidney Diseases
Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine (colon). Irritable bowel syndrome commonly causes cramping, abdominal pain, bloating, gas, diarrhea and constipation. IBS is a chronic condition that you will need to manage long term.
Even though signs and symptoms are uncomfortable, IBS — unlike ulcerative colitis and Crohn’s disease, which are forms of inflammatory bowel disease — doesn’t cause changes in bowel tissue or increase your risk of colorectal cancer.
Only a small number of people with irritable bowel syndrome have severe signs and symptoms. Some people can control their symptoms by managing diet, lifestyle and stress. Others will need medication and counseling.
The signs and symptoms of irritable bowel syndrome can vary widely from person to person and often resemble those of other diseases. Among the most common are:
When to see a doctor:
Although as many as 1 in 5 American adults has signs and symptoms of irritable bowel syndrome, fewer than 1 in 5 who have symptoms seek medical help. Yet it’s important to see your doctor if you have a persistent change in bowel habits or if you have any other signs or symptoms of IBS because these may indicate a more serious condition, such as colon cancer.
Symptoms that may indicate a more serious condition or tell your MD stat; even call 911:
Causes of IBS:
The exact cause of irritable bowel syndrome (IBS) has not been determined, although there are several theories. One theory is that IBS may be an immune disorder, or one in which the intestines of the affected person are highly sensitive in responding to stress and bacteria. Certain foods are thought to trigger IBS flare-ups, including dairy products and gluten, which is present in wheat, barley and rye.
The epithelial layer, or lining, of the large intestine controls the amount of fluid in the bowel. In IBS, there appears to be a disruption in the function of fluid absorption. This can result in excessive fluid in the colon, which causes diarrhea and watery stools. Or, if the lining of the colon absorbs too much fluid from the colon contents, the stool may become dry, leading to constipation.
“Benign prostatic hyperplasia (BPH) — also called prostate gland enlargement — is a common condition as men get older. An enlarged prostate gland can cause uncomfortable urinary symptoms, such as blocking the flow of urine out of the bladder. It can also cause bladder, urinary tract or kidney problems.”
MAYO CLINIC
“-BETWEEN 4 AND 10 OUT OF 1,000: Number of people on earth who live with active seizures at any one time.
-150,000: Number of new cases of epilepsy in the United States each year
=ONE-THIRD: Number of people with epilepsy who live with uncontrollable seizures because no available treatment works for them.
-6 OUT OF 10: Number of people with epilepsy where the cause is unknown.”
Epilepsy Foundation
Types of seizures
I-Partial seizures (seizures beginning local)
1-simple partial seizures-(the person is conscious and not impaired). With motor symptoms, autonomic symptoms and even psychic symptoms.
2.)-Complex partial seizures-(the person is with impairment of consciousness)
II-Generalized seizures-(bilaterally symmetrical and without local onset).
3.) Tonic clonic seizures – Grand Mal
Diagnosis
The history of the person is the most valuable component of the workup of that individual with possible epilepsy.
The routine diagnostic tooling to see if someone has this disease is a EEG which is the major diagnostic test. EEG takes short samples of brain wave activity with 26 wires to the scalp recording amplified brain waves from the superficial regions of the brain by means of scalp electrodes.
Laboratory studies are done to rule out various causes for seizures. Routine blood and urine studies are often done for baseline information. Electrolytes and blood chemistries will be evaluated to identify possible metabolic causes for seizures.
Neuropsychological testing may be done in the evaluation of persons presenting with seizures. The purpose of neuropsychological testing is to determine if there is brain dysfunction and to determine if the pattern of change in brain function is indicative of a destructive lesion. Neuropsychological testing involves evaluation of cognitive functions and personality and emotional traits.
Medical Management
The major medical treatment for epilepsy is antiepileptic medications. Epileptic seizures can be controlled in 50 to 95% of cases with this form of treatment depending on seizure type and compliance of the individual taking their medications.
Those taking medications for epilepsy know if a single first line drug is not effective a second first lin drug is added but the noneffective drug is tapered off while the second first line drug is given. Know during this time frame there is a risk for seizure activity so practice safety (ex. do not drive).
In some cases there is surgery: those with intractable seizures is the epileptic focus may be possible. In some cases partial complex seizures are the common seizure treated by surgery. The focus of this seizure type has often been found in the anterior temporal and inferior frontal regions of the brain cortex.
There are other treatments as well.
Care during a Seizure
The care of a person in a seizure should focus primarily on maintaining a safe environment. The seizure that has greatest risk for causing injury and even fatality is the generalized tonic/clonic (grand mal), although there is a potential for injury with any seizure that involves alteration of consciousness.
The 2 major goals for care during a seizure are protection from injury and prevention of aspiration. The person’s head should be cradled if on the floor to prevent banging of the head. At no time should the person be restraint when having a seizure. The person should be turned to their side to allow the tongue to fall away from the airway and allow drainage of the excessive saliva that accumulates to drain out of the mouth during the seizure. You should stay with the person till the seizure stops and note the behavior mentally and physically the person exhibits while having the seizure and how long it lasts. Immediately call 911 (especially if this is the first seizure the person ever had) or call the neurologist of the individual to have the him or her be evaluated ASAP.
“-65 MILLION: Number of people around the world who have epilepsy.
-3.4 MILLION: Number of people in the United States who have epilepsy.
-1 IN 26 people in the United States will develop epilepsy at some point in their lifetime.”
Epilepsy Foundation
Most people with epilepsy are otherwise healthy; as long as it is controlled like most other diseases. A seizure is a physical manifestation of paroxysmal and abnormal electrical firing of neurons in the brain. Think of it as numerous voltage (hyperexcitability of neurons) going throughout the brain meaning brain waves going in all directions with the brain saying its too much activity causing the brain to go into a seizure.
When the seizure occurs there is a decrease in oxygen since the brain isn’t capable to send messages during the seizure. If the seizure continues to repeat one right after another the person is in status epilepticus and if the seizures doesn’t stop the person can lead to a neuronal death; like John Travolta’s son who died of this.
The term seizure disorder may refer to any number of conditions that result in such a paroxysmal electrical discharge. These conditons could be metabolic or structural in nature. Epilepsy is the term for those who have a second seizure that occurs spontaneously and without preceding metabolic or structural cause for the occurrence. Epilepsy is a chronic disorder that requires antiepileptic drug therapy; usually thorough out life.
Etiology of Epilepsy is generally a sign of underlying pathology involving the brain. It may be the first sign of nervous system disease (ex. Brain tumor), or it may be a sign of a systemic or metabolic derangement.
Metabolic and Systemic Causes of Seizures:
a.) Electrolyte Imbalance=Acidosis, heavy metal poisoning, Hypocalcemia, Hypocapnea, Hypoglycemia, Hypoxia, Sodium-Potassium imbalance, Systemic diseases (liver, renal failure, etc…) Toxemia of pregnancy, and water intoxication.
b.) Infections like meningitis, encephalitis, brain abcess.
c.) Withdrawal of sedative-hypnotic drugs=Alcohol, Antiepileptic drugs, Barbiturates, Benzodiazepines.
d.) Iatrogenic drug overdose=Theopylline, Penicillin.
Other causes of epilepsy can be Trauma, Heredity.
“Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). A novel coronavirus (nCoV) is a new strain that has not been previously identified in humans. Coronaviruses are zoonotic, meaning they are transmitted between animals and people. Detailed investigations found that SARS-CoV was transmitted from civet cats to humans and MERS-CoV from dromedary camels to humans. Several known coronaviruses are circulating in animals that have not yet infected humans.”
World Health Organizations (WHO)
2019 Novel Coronavirus (2019-nCoV) is a virus (more specifically, a coronavirus) identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China. Early on, many of the patients in the outbreak in Wuhan, China reportedly had some link to a large seafood and animal market, suggesting animal-to-person spread. However, a growing number of patients reportedly have not had exposure to animal markets, indicating person-to-person spread is occurring. At this time, it’s unclear how easily or sustainably this virus is spreading between people.
Much is unknown about how 2019-nCoV, a new coronavirus, spreads. Current knowledge is largely based on what is known about similar coronaviruses. Coronaviruses are a large family of viruses that are common in many different species of animals, including camels, cattle, cats, and bats. Rarely, animal coronaviruses can infect people and then spread between people such as with MERS, SARS, and now with 2019-nCoV.
Most often, spread from person-to-person happens among close contacts (about 6 feet). Person-to-person spread is thought to occur mainly via respiratory droplets produced when an infected person coughs or sneezes, similar to how influenza and other respiratory pathogens spread. These droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs. It’s currently unclear if a person can get 2019-nCoV by touching a surface or object that has the virus on it and then touching their own mouth, nose, or possibly their eyes.
Typically, with most respiratory viruses, people are thought to be most contagious when they are most symptomatic (the sickest).
It’s important to note that how easily a virus spreads person-to-person can vary. Some viruses are highly contagious (like measles), while other viruses are less so. There is much more to learn about the transmissibility, severity, and other features associated with 2019-nCoV and investigations are ongoing.
For confirmed 2019-nCoV infections, reported illnesses have ranged from people with little to no symptoms to people being severely ill and dying. Symptoms can include:
CDC has developed a new laboratory test kit for use in testing patient specimens for 2019 novel coronavirus (2019-nCoV). The test kit is called the “Centers for Disease Control and Prevention (CDC) 2019-Novel Coronavirus (2019-nCoV) Real-Time Reverse Transcriptase (RT)-PCR Diagnostic Panel.” It is intended for use with the Applied Biosystems 7500 Fast DX Real-Time PCR Instrument with SDS 1.4 software. This test is intended for use with upper and lower respiratory specimens collected from persons who meet CDC criteria for 2019-nCoV testing. CDC’s test kit is intended for use by laboratories designated by CDC as qualified, and in the United States, certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity tests. The test kits also will be shipped to qualified international laboratories, such as World Health Organization (WHO) Global Influenza Surveillance Response System (GISRS) laboratories.
PREVENTION:
There is currently no vaccine to prevent 2019-nCoV infection. The best way to prevent infection is to avoid being exposed to this virus. However, as a reminder, CDC always recommends everyday preventive actions to help prevent the spread of respiratory viruses, including:
“Age-related macular degeneration (AMD) is a problem with your retina. It happens when a part of the retina called the macula is damaged. With AMD you lose your central vision. You cannot see fine details, whether you are looking at something close or far. But your peripheral (side) vision will still be normal.”
American Academy of Ophthalmology