“People were followed for periods ranging from three to 11 years, depending on the study, using questionnaires, interviews, and self-reports on medication use.The analysis revealed a 20% higher risk of autism and a 30% higher risk of ADHD for children who had prolonged exposure to acetaminophen during fetal development.

However, it noted that taking small amounts of acetaminophen during pregnancy — in one study, for fewer than eight days — didn’t increase risks.

Other studies since then have supported earlier findings that too much acetaminophen may increase one’s risk for autism and ADHD.”

Cleveland Clinic (https://health.clevelandclinic.org/pregnancy-does-acetaminophen-heighten-risks-for-autism-adhd/)

“Acetaminophen is one of the most commonly used drugs during pregnancy globally. Recent studies have reported associations between prenatal exposure to acetaminophen and neurobehavioral problems in children, including attention-deficit hyperactivity disorders. Little research has investigated these associations in preschool-age children or the potential confounding effects of prenatal stress.  Acetaminophen use during pregnant may also disrupt the maternal and fetal gut microbiota leading to neurodevelopmental problems [18, 19]. Another possible mechanism of the association between prenatal acetaminophen use and neurobehavioral problems in childhood is prenatal stress.”

National Library of Medicine (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518858/)

Harvard Health Publishing states the following

“For years, products containing acetaminophen, such as the pain reliever Tylenol, were largely viewed as safe to take during pregnancy. Hundreds of widely available over-the-counter remedies, including popular cold, cough, and flu products, contain acetaminophen. Not surprisingly, some 65% of women in the US report taking it during pregnancy to relieve a headache or to ease an aching back.

But recently, a group of doctors and scientists issued a consensus statement in Nature Reviews Endocrinology urging increased caution around acetaminophen use in pregnancy. They noted growing evidence of its potential to interfere with fetal development, possibly leaving lingering effects on the brain, reproductive and urinary systems, and genital development. And while the issue they raise is important, it’s worth noting that the concerns come from studies done in animals and human observational studies. These types of studies cannot prove that acetaminophen is the actual cause of any of these problems.

Acetaminophen is known to be an endocrine disruptor. That means it can interfere with chemicals and hormones involved in healthy growth, possibly throwing it off track.

According to the consensus statement, some research suggests that exposure to acetaminophen during pregnancy — particularly high doses or frequent use — potentially increases risk for early puberty in girls, or male fertility problems such as low sperm count. It is also associated with other issues such as undescended testicles, or a birth defect called hypospadias where the opening in the tip of the penis is not in the right place. It might play a role in attention deficit disorder and negatively affect IQ.

Risks for ill effects are low

If you took acetaminophen during a current or past pregnancy, this might sound pretty scary — especially since you’ve probably always considered this medicine harmless. But while experts agree it’s important to consider potential risks when taking any over-the-counter or prescription medicines during pregnancy, you shouldn’t panic.

“The risk for an individual is low,” says Dr. Kathryn M. Rexrode, chief of the Division of Women’s Health, Department of Medicine at Harvard-affiliated Brigham and Women’s Hospital.

Chances are pretty good that if you took acetaminophen during a pregnancy, your baby likely did not, or will not, suffer any ill effects.

The research on this topic is not conclusive. Some information used to inform the consensus statement was gathered from studies on animals, or human studies with significant limitations. More research is needed to confirm that this medicine is truly causing health problems, and to determine at what doses, and at what points during a pregnancy, exposure to acetaminophen might be most harmful.

Sensible steps if you’re pregnant

Three common-sense steps can help protect you and your baby until more is known on this topic:

• Avoid acetaminophen during pregnancy when possible. Previously during preconception and pregnancy counseling, Dr. Rexrode had warned patients against using NSAID drugs, such as Advil and Aleve, and suggested taking acetaminophen instead. “Now I also tell people that some concerns have been raised about acetaminophen use during pregnancy, and explain that its use should be limited to situations where it is really needed,” says Dr. Rexrode. In short, always consider whether you really need it before you swallow a pill.
• Consult with your doctor. Always clear acetaminophen use with your doctor, particularly if you are going to be using the medicine for a long period of time. They might agree that taking it is the best option — or suggest a safer alternative.
• Minimize use. If you do need to take acetaminophen during pregnancy, take it for the shortest amount of time possible and at the lowest effective dose to reduce fetal exposure. “This advice about the lowest necessary dose for the shortest period of time is generally good counseling for all over-the-counter medication use, especially during pregnancy,” says Dr. Rexrode.

While all of this is good advice for using acetaminophen, there are times when it’s riskier not to take it. For example, if you have a high fever during pregnancy — which can harm your baby — acetaminophen may be needed to bring your fever down. Provided it’s advised by your doctor, the benefits of acetaminophen use in this case outweigh the potential risks.”

Harvard Health Publishing is the media and publishing division of the Harvard Medical School of Harvard University, under the direction of Dr. David H. Roberts, Dean for External Education.

“Stroke is the third most common overall cause of death and the leading cause of adult disability in the United States. New therapeutic interventions instituted in the period immediately after a stroke have revolutionized the approach to ischemic cerebrovascular disease. Recognition of a transient ischemic attack provides an opportunity to prevent a subsequent stroke. Specific stroke prevention treatment depends on the cause of the transient ischemic attack, its cerebrovascular localization and the presence of associated coexisting medical problems. Modification of stroke risk factors is the principal therapeutic approach. Antiplatelet agents and anticoagulants have been shown to be effective in reducing the occurrence of stroke in certain populations.”

American Family Physician (https://www.aafp.org/pubs/afp/issues/1999/1115/p2329.html)

There are 2 types of strokes:

1-Hemmoragic-a blood vessel that bursts in the brain causing lack of oxygen to be supplied to the area of the brain (a lobe) where the vessel ruptured.  Lack of oxygen to any area of the body tissue=starvation to the tissue; where in this case is the brain=a stroke.

2-Ischemic=Blockages-These blockages caused by the following: blood clots, athero-sclerosis, a common disorder, it happens due to fat, cholesterol, with even tar from smoking, or other substances that build up in the walls of the arteries forming hard structures called plaque and in time creating a blockage in the vessel interfering with blood supply providing oxygen to tissue and if blocked in the brain=high probability of a stroke occurring if not taken care of.   “Recommended related to Heart Disease” by Web MD which states that atherosclerosis is the key cause of heart attacks & strokes including it’s the number one killer in the United States.  Risk Factors for atherosclerosis include high blood pressure (b/p)=arteriosclerosis, blood level of high bad cholesterol (LDL), blood level of low good cholesterol (HDL), smoking, diabetes, and history of heart attacks in your nuclear family.  Definitely a healthy diet, having exercise in your life, and your weight within the therapeutic body mass index level will help prevent, if not treat, atherosclerosis.

The Risk Factors of this disease that include:

1.) High Blood Pressure (b/p)-This is also known as the diagnosis hypertension.  In understanding how hypertension works let’s use a metaphor:  Think of a blood vessel as a long thin balloon and if we stand on it the pressure will increase inside the balloon causing the diameter of the balloon to swell up.  If you continue to step on the balloon adding additional pressure this causes it to finally reach it’s total amount of pressure or when you exceed the total level of pressure this results in popping the balloon.  Similar concept with high b/p, that’s if the pressure keeps rising in our blood vessels due to blockage or vasoconstriction (which is making the vessels diameter more narrow=increased pressure in the vessels) sooner or later a vessel bursts somewhere in the body due to the b/p passing it’s total level in the amount of pressure that it can handle in the circulatory system which can result into a burst of an artery, like in the brain causing a stroke or in a vessel near the heart causing a myocardial infarction (but this is another topic some other day).  Think of food,  a human being not eating leads into starvation, well for blood cells lack of oxygen=starvation to the cells.  This causes in both situations or cases a lack of nutrition (the tissue is lacking oxygen).  With a stroke, not enough oxygen is getting to the brain resulting from either a hemorrhage (loosing too much blood=loosing to many cells=oxygen (food for tissue) or a blockage preventing 02 getting to the area.  Though many people have increased b/p due to only 2 things diet leading them to obesity, and lack of exercise due to a sedentary lifestyle, which could be changed and resolve the problem in most cases.  Increased b/p can also be due noncompliance- like continuing to smoke, or not following the healthy regimen the M.D. ordered for you as a patient.  The overall healthy regimen for a person with hypertension would be a low sodium diet (preventing further vasoconstriction), even low in cholesterol/fat/1800-2000 calories a day (preventing obesity or further weight gain), balancing rest with exercise and the b/p medications taken as prescribed, by their M.D.    So for many Americans hypertension can be controlled just by diet with balancing exercise with rest.  For others it might take a little more like doing which is what I just mentioned with following your medication regimen as ordered and going to your doctor having your b/p monitored, as your M.D. prescribes.

2.) Smoking-For starters, this unhealthy habit puts you at risk for high blood pressure since it causes vasoconstriction (narrowing) of the vessels in our body due to the nicotine.  The answer to this risk factor is simply quit this unhealthy habit. I have a dear friend doing great in quitting this habit now. Smoking adds to the plaque building up in the vessels.  Centers for Disease state that in 2010 the leading cause of death was heart disease followed by cancer than to chronic respiratory disease and lastly stroke.  Over time a healthy diet balanced with exercise daily or every 2 days for 30minutes would help decrease the cardiac disease and stroke.  The American Lung Association states that smoking is directly responsible for approximately 90 percent of lung cancer deaths and approximately 80-90 percent of COPD (emphysema and chronic bronchitis) deaths.

• Among adults who have ever smoked, 70% started smoking regularly at age 18 or younger, and 86% at age 21 or younger.
• Smoking harms nearly every organ in the body, and is a main cause of lung cancer and chronic obstructive pulmonary disease (COPD, including chronic bronchitis and emphysema). It is also a cause of coronary heart disease (CAD), stroke and a host of other cancers and diseases.

3.) Cholesterol is also found in some foods, such as seafood, eggs, meats and dairy products.LDL can cause plaque build-up. Plaque is a thick, hard substance that can clog arteries. Recent studies show that high levels of LDL and triglycerides (blood fats) raise the risk of ischemic stroke. Plaque can also increase risk of a transient ischemic attack (TIA) where stroke symptoms go away within 24 hours.

• The second main type of cholesterol is high-density lipoprotein (HDL), often called the “good” cholesterol. High levels of HDL may reduce stroke risk.
• Because cholesterol does not dissolve in the blood on its own, it must be carried to and from cells by particles called lipoproteins. There are two main types of lipoproteins: low-density lipoproteins (LDL)=the bad cholesterol and high-density lipoproteins=the good cholesterol (HDL).
• The National Stroke Association states the following about cholesterol: Cholesterol is a soft, waxy fat (lipid) that is made by the body. It is found in the bloodstream and in all of your body’s cells. The body needs cholesterol to form cell membranes, some hormones and vitamin D.
• So let’s take a car for instance, if the transmission is bad and not repaired by a mechanic the engine will be affected and soon fail completely.  Now let’s take the lungs, if they are bad and you don’t go to a doctor to help treat the problem the heart will be affected at some point to failure in function. This is the same with a heart (the engine of the body), that when it is bad with no repair or Rx it will soon affect the lungs (the transmission of the body). When one of these organs works at its fullest potential without the other organ properly functioning, in time, it will affect the other organ.  If a smoker doesn’t quit it causes COPD=Emphysema (this does take over years) and it will affect the heart in time to not function as effectively with someone who has healthy lungs.  Worse, if you don’t quit smoking you increase the risk of getting CAD (coronary artery disease) and add to the problem atherosclerosis, if you already have the diagnosis which is caused by fatty materials (lipids), fibrous tissue with tar (from the smoking) causing blockages in the vessels or even better cause arteriosclerosis (narrowing of the vessels). You also have a risk at lung cancer.

4.) Diet & Sedentary lifestyle as factors especially!!

Stroke verses TIA=Nonreversible verses Reversible:

• Stroke is scarring to the brain where TIA doesn’t.  Like Heart Attack verses Angina, Heart Attack is scarring to the heart verses no scarring to the heart with Angina. Both Angina and TIA are just lack of oxygen to the heart and the brain, causing the symptoms due to lack of oxygen=ischemia.  Both heart attack and stroke are both a lot worse than just ischemia.  They both get to the point where there in no oxygen causing actual permanent damage to the organ since the problem never reversed=scarring to the heart and brain.High cholesterol levels or plaque build-up in the arteries can block normal blood flow to the brain and cause a stroke. High cholesterol may also increase the risk of heart disease and atherosclerosis, which are both risk factors for stroke.                                                               
• I have a dear friend who I’ve known almost 35 years that survived coronary artery bypass surgery over 55 y/o, with 5 blockages (2 arteries 100% blocked and 3 arteries at least 80% blocked=5 vessels blocked).  That was a set up for a silent heart attack if he didn’t have the surgery but he was lucky in getting symptoms of chest pain and fatigue/lethargy due to these blockages.  This made him go the doctor.  He stopped smoking the day before the surgery.   His life had taken a 360 turn and stopped in his daily routine and life schedule.  It had begun all over again at almost 60.   Without controlling your blood pressure therapeutically or without ending your smoking or without eating healthy with living healthy habits the heart at first will be able to compensate with living unhealthy habits but over time the heart may find it so hard to function or work that the heart starts to fail in doing its job effectively (it decompensates causing to go into failure if no changes are made).  Again let’s take a car, you do maintenance to the vehicle for it will operate and last longer, well the exact principle with the human body.  Pretty simple isn’t it.
• Good Diet, Good Exercise balanced with rest, and no smoking with B/P well controlled.

If you don’t eat a healthy diet, keep your weight in a therapeutic range, properly exercise than expect to be at high odds you will be leaning more towards shortening your life span.  You can control your diet, weight and your exercise the right way with a little direction.  There is many places for just that direction in helping you maintain a good diet including weight and giving you guidance whether it be at a clinic, work out facility or a weight loss food place via the community or internet with or by yourself but recommended to use simply a book.

It is recommended to go to your M.D. first before making any changes for the doctor will know all your medical history and can give you the right direction in what’s the best route for you in reaching your goals.

“Choose face paint and makeup whenever possible instead of masks, which can obstruct a child’s vision.  Popular trick-or-treating hours are 5:30 p.m. to 9:30 p.m. Be especially alert for kids during those hours.  Join kids under age 12 for trick-or-treating. If kids are mature enough to be out without supervision, tell them to stick to familiar areas that are well lit and trick-or-treat in groups.”

SAFE KIDS Worldwide (https://www.safekids.org/tip/halloween-safety-tips)

Treats: Warn children not to eat any treats before an adult has carefully examined them for evidence of tampering.

Flame Resistant Costumes: When purchasing a costume, masks, beards, and wigs, look for the label Flame Resistant. Although this label does not mean these items won’t catch fire, it does indicate the items will resist burning and should extinguish quickly once removed from the ignition source. To minimize the risk of contact with candles or other sources of ignition, avoid costumes made with flimsy materials and outfits with big, baggy sleeves or billowing skirts.

Costume Designs: Purchase or make costumes that are light and bright enough to be clearly visible to motorists.

For greater visibility during dusk and darkness, decorate or trim costumes with reflective tape that will glow in the beam of a car’s headlights.

Bags or sacks should also be light colored or decorated with reflective tape. Reflective tape is usually available in hardware, bicycle, and sporting goods stores.

To easily see and be seen, children should also carry flashlights.

Costumes should be short enough to prevent children from tripping and falling.

Children should wear well-fitting, sturdy shoes . Mother’ s high heels are not a good idea for safe walking.

Hats and scarfs should be tied securely to prevent them from slipping over children’s eyes.

Apply a natural mask of cosmetics rather than have a child wear a loose-fitting mask that might restrict breathing or obscure vision. If a mask is used, however, make sure it fits securely and has eyeholes large enough to allow full vision. Swords, knives, and similar costume accessories should be of soft and flexible material.

Pedestrian Safety: Young children should always be accompanied by an adult or an older, responsible child. All children should WALK, not run from house to house and use the sidewalk if available, rather than walk in the street.

Children should be cautioned against running out from between parked cars, or across lawns and yards where ornaments, furniture, or clotheslines present dangers.

Choosing Safe Houses: Children should go only to homes where the residents are known and have outside lights on as a sign of welcome.

Children should not enter homes or apartments unless they are accompanied by an adult.

People expecting trick-or-treaters should remove anything that could be an obstacle from lawns, steps and porches.

Candlelit jack-o’-lanterns should be kept away from landings and doorsteps where costumes could brush against the flame. Indoor jack-o’-lanterns should be kept away from curtains, decorations, and other furnishings that could be ignited.

Even though it’s not an official holiday, Halloween is much beloved by children and adults alike. What could be more fun than trick-or-treating, apple bobbing, or costume parties?

To make sure treats are safe for children, follow these simple steps:

Snacking: Children shouldn’t snack on treats from their goody bags while they’re out trick-or-treating. Give them a light meal or snack before they head out – don’t send them out on an empty stomach. Urge them to wait until they get home and let you inspect their loot before they eat any of it.

 Safe treats: Tell children not to accept – and especially not to eat – anything that isn’t commercially wrapped. Inspect commercially wrapped treats for signs of tampering, such as an unusual appearance or discoloration, tiny pinholes, or tears in wrappers. Throw away anything that looks suspicious.

 Food Allergies: If your child has a food allergy, check the label to ensure the allergen isn’t present. Do not allow the child to eat any home-baked goods he or she may have received.

 Choking hazards: If you have very young children, be sure to remove any choking hazards such as gum, peanuts, hard candies, or small toys.

 Bobbing for apples is an all-time favorite Halloween game. Here are a couple of ways to say “boo” to bacteria that can cause foodborne illness. Reduce the number of bacteria that might be present on apples and other raw fruits and vegetables by thoroughly rinsing them under cool running water. As an added precaution, use a produce brush to remove surface dirt.

Try this new spin on apple bobbing from FightBAC.org: Cut out lots of apples from red construction paper. On each apple, write activities for kids, such as “do 5 jumping jacks.” Place a paper clip on each apple and put them in a large basket. Tie a magnet to a string. Let the children take turns “bobbing” with their magnet and doing the activity written on their apple. Give children a fresh apple for participating.

If your idea of Halloween fun is a party at home, don’t forget these tips: 

• Beware of spooky cider! Unpasteurized juice or cider can contain harmful bacteria such as Salmonella. To stay safe, always serve pasteurized products at your parties.
• No matter how tempting, don’t taste raw cookie dough or cake batter that contain uncooked eggs.
• “Scare” bacteria away by keeping all perishable foods chilled until serving time. These include finger sandwiches, cheese platters, fruit or tossed salads, cold pasta dishes with meat, poultry, or seafood, and cream pies or cakes with whipped-cream and cream-cheese frostings.

Bacteria will creep up on you if you let foods sit out too long. Don’t leave perishable goodies out of the fridge for more than two hours (1 hour in temperatures above 90°F).

“Here’s a scary statistic: Children are more than twice as likely to be hit by a car and killed on Halloween than on any other day of the year. Lack of visibility because of low lighting at night also plays a factor in these incidents.  A responsible adult should accompany young children on the neighborhood round.  If your older children are going alone, plan and review a route acceptable to you. Agree on a specific time children should return home.  Watch for children walking on roadways, medians and curbs.  Enter and exit driveways and alleys carefully.  All costumes, wigs and accessories should be fire-resistant.  If children are allowed out after dark, fasten reflective tape to their costumes and bags, or give them glow sticks.”

National Safety Council NSC (https://www.nsc.org/community-safety/safety-topics/seasonal-safety/autumn-safety/halloween)