“Although closely related, the treatment and prognosis varies greatly between actinic keratosis (AK), keratoacanthoma (KA), and other skin cancers; therefore, an accurate diagnosis is essential. Immunohistochemistry (IHC) has been explored as a possible means to differentiate between AK, KA, and others.”.

The Journal of the American Academy of Dermatology (https://www.jaad.org/article/S0190-9622(19)31299-X/fulltext).